6 курс / Медицинская реабилитация, ЛФК, Спортивная медицина / Научные тренды продления жизни

Основные публикации

по теме

Aging of different avian cultured cells: Lack of ROS-induced damage and quality control

mechanisms. Strecker V, Mai S, Muster B, Beneke S, Bürkle A, Bereiter-Hahn J, Jendrach M.

Mech Ageing Dev. 2009

Rapamycin inhibits poly(ADP-ribosyl)ation in intact cells. Fahrer J, Wagner S, Bürkle A,

Königsrainer A. Biochem Biophys Res Commun 2009;386:232-236.

DNA repair and PARP in aging. Bürkle A. Free Radic Res. 2006 Dec;40(12):1295-1302.

L1 and carbonyl-modified UCH-L1. Kabuta T, Setsuie R, Mitsui T, Kinugawa A, Sakurai M,

Aoki S, Uchida K, Wada K. Hum Mol Genet. 2008 May 15;17(10):1482-96.

Insights into links between familial and sporadic Parkinson’s disease: Physical relationship be-

tween UCH-L1 variants and chaperone-mediated autophagy. Kabuta T, Wada K. Autophagy.

2008 Aug 16;4(6):827-9.

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosom-

al Receptor for Chaperone-mediated Autophagy. Tomohiro Kabuta, Akiko Furuta, Shunsuke

Aoki, Koh Furuta and Keiji Wada. J Biol Chem. 2008 Aug 29; 283(35):23731-8.

Genome Dynamics and Transcriptional Deregulation in Aging Rita Busuttil, Rumana Bahar,

and Jan Vijg Neuroscience. 2007 Apr 14;145(4):1341-7.

Epigenetic factors in aging and longevity. Gravina S, Vijg J. Pflugers Arch. 2010

Jan;459(2):247-58.

Aging and genome maintenance: lessons from the mouse? Hasty P, Campisi J, Hoeijmakers J,

van Steeg H, Vijg J. Science. 2003 Feb 28;299(5611):1355-1359.

Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neu-

rogenesis, and deficits in fine olfactory discrimination. Enwere E, Shingo T, Gregg C, Fujikawa

генетика, мовлияющие на него фак-

H, Ohta S, Weiss S. J Neurosci. 2004 Sep 22;24 (38):8354-65.

Immunobiology of oligodendrocytes in multiple sclerosis, Ruffini F, Chojnacki A, Weiss S, Antel

JP. Adv Neurol. 2006. 98:47-63.

Radial glial cells as neuronal precursors: the next generation?, Gregg CT, Chojnacki AK, Weiss

S. J. Neurosci Res. 2002 Sep 15. 69(6):708-13.

Hematopoietic stem and progenitor cells and the inflammatory response. Jaiswal S, Weissman

IL. Ann N Y Acad Sci. 2009. 1174:118-21.

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid

leukemia stem cells. Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD Jr, van

Rooijen N, Weissman IL.Cell. 2009. 138(2):286-99.

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche. Ootani

A, Li X, Sangiorgi E, Ho QT, Ueno H, Toda S, Sugihara H, Fujimoto K, Weissman IL, Capec-

chi MR, Kuo CJ. Nat Med. 2009. 15(6):701-6.

Основные публикации

по теме

Tissue Transglutaminase, Protein Cross-linking and Alzheimer's Disease: Review and Views.

Wang DS, Dickson DW, Malter JS. Int J Clin Exp Pathol. 2008. 1(1):5-18.

Neuroprotective activities of enzymatically hydrolyzed peptides from porcine hide gelatin.

Wang S, Wang DS, Wang R. Int J Clin Exp Med. 2008.1(3):283-93. 2008.

Beta-Amyloid Degradation and Alzheimer's Disease. Wang DS, Dickson DW, Malter JS. J

Biomed Biotechnol. 2006(3):58406.

Effect of Monascus-fermented products on learning and memory in the SAMP8 mice. Ou

HP, Wang MF, Yang SC, Yamamoto S, Wang CC. J Nutr Sci Vitaminol (Tokyo). 2007

Jun;53(3):253-60.

Favorable effects of tea on reducing the cognitive deficits and brain morphological changes in

senescence-accelerated mice. Chan YC, Hosoda K, Tsai CJ, Yamamoto S, Wang MF. J Nutr Sci

Vitaminol (Tokyo). 2006 Aug;52(4):266-73.

Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated

with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. Wang Y, Ausman

LM, Russell RM, Greenberg AS, Wang XD. J Nutr. 2008 Oct;138(10):1866-1871.

Apo-10’-lycopenoic acid induces Nrf2-mediated expression of phase II detoxification and an-

tioxidant enzymes in human bronchial epithelial cells. Lian F, and Wang X-D. International

Journal of Cancer. 2008;123:1262-1268.

Lycopene metabolites, apo-10’-lycopenoic acid, inhibits the growth of lung cancer cells in vitro

and suppresses lung carcinogenesis in A/J mice in vivo. Lian F, Smith D, Ernst H, Russell

RM, Wang X-D. Carcinogenesis. 2007;28:1567-1574.

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP

neurons. Claret,M., Smith,M.A., Batterham,R.L., Selman,C., Choudhury,A., Fryer,L.G.D.,

Clements,M., Al-Qassab,H., Heffron.H., Xu,A.W., Speakman,J.R., Barsh,G.S., Viollet,B.,

Vaulont,S., Ashford,M.L.J., Carling,D., Withers,D.J. Journal of Clinical Investigation.

2007. 117(8), 2325-2336.

Evolutionarily conservation of regulated longevity assurance mechanisms. McElwee,J.J.,

Schuster,E., Blanc,E., Piper,M.D., Thomas,J.H., Patel,D.S., Selman,C., Withers,D.J.,

Thornton,J.M., Partridge,L., Gems,D.H. Genome Biology. 2007. 8(7), R132.

Willcox DC, Willcox BJ, Wang NC, He Q, Rosenbaum M, Suzuki M. Life at the extreme

limit: phenotypic characteristics of supercentenarians in Okinawa. J Gerontol A Biol Sci Med

Sci. 2008 Nov;63(11):1201-8.

Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodri-

guez B, Curb JD. FOXO3A genotype is strongly associated with human longevity.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13987-92. Epub 2008 Sep 2.

Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, Curb JD, Suzuki M. Caloric

restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-

lived people and its potential impact on morbidity and life span. Ann N Y Acad Sci. 2007

Oct;1114:434-55.

Основные публикации

по теме

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Sauve

AA, Moir RD, Schramm VL, Willis IM.

Protein kinase A regulates RNA polymerase III transcription through the nuclear localization

of Maf1. Moir RD, Lee J, Haeusler RA, Desai N, Engelke DR, Willis IM, 2006.

Integration of nutritional and stress signaling pathways by Maf1. Willis IM, Moir RD, 2007.

tion studies of individuals 20-100 years of age. Wikby A, Månsson IA, Johansson B, Strindhall

J. Biogerontology 2008; 9:299-308.

Cytomegalovirus and human immunosenescence

Pawelec G, Derhovanessian E, Larbi A, Strindhall J, Wikby A. Rev Med Virol 2009; 19:47-56

Activin in the brain modulates anxiety-related behavior and adult neurogenesis. Ageta H, Mu-

rayama A, Migishima R, Kida S, Tsuchida K, Yokoyama M, Inokuchi K.PLoS One. 2008 Apr

2;3(4):1869.

Activin and basic fibroblast growth factor regulate neurogenesis of murine embryonal carci-

noma cells. Ameerun RF, de Winter JP, van den Eijnden-van Raaij AJ, den Hertog J, de Laat

SW, Tertoolen LG.Cell Growth Differ. 1996 Dec;7(12):1679-88.

RA, Stewart M, Roth M. J Cell Biol. 1985 100(6):1905-12.

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of

Alzheimer disease: identification as the microtubule-associated protein tau. Goedert M, Wis-

chik CM, Crowther RA, Walker JE, Klug A. Proc Natl Acad Sci. 198885(11):4051-5

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Wischik

CM, Edwards PC, Lai RY, Roth M, and Harrington CR. Proc Natl Acad Sci . 1996 93(20):

11213–11218.

Identifying advanced glycation end products as a major source of oxidants in aging:

implications for the management and/or prevention of reduced renal function in elderly

persons. Vlassara H, Uribarri J, Ferrucci L, Cai W, Torreggiani M, Post JB, Zheng F, Striker

GE. Semin Nephrol. 2009 Nov;29(6):594-603.

Protection against loss of innate defenses in adulthood by low advanced glycation end products

(AGE) intake: role of the antiinflammatory AGE receptor-1. Vlassara H, Cai W, Goodman

S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman

L, Striker GE, Uribarri J. J Clin Endocrinol Metab. 2009 Nov;94(11):4483-91.

Cryopreservation of complex systems: the missing link in the regenerative medicine supply

chain. Fahy GM, Wowk B, Wu J. Rejuvenation Res. 2006 Summer;9(2):279-91. Review.

Erratum in: Rejuvenation Res. 2006 Winter;9(4):509.

Основные публикации

по теме

Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery af-

ter transient cerebral ischemia. Wei L, Cui L, Snider BJ, Rivkin M, Yu SS, Lee CS, Adams LD,

Gottlieb DI, Johnson EM Jr, Yu SP, Choi DW. Neurobiol Dis. 2005 Jun-Jul;19(1-2):183-93.

Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in

rats. Wei L, Ying DJ, Cui L, Langsdorf J, Yu SP. Brain Res. 2004 Oct 1;1022(1-2):54-61.

RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Sebastiani P, Montano M, Puca A, Solovieff N, Kojima T, Wang MC, Melista E, Meltzer

M, Fischer SE, Andersen S, Hartley SH, Sedgewick A, Arai Y, Bergman A, Barzilai N, Terry

DF, Riva A, Anselmi CV,Malovini A, Kitamoto A, Sawabe M, Arai T, Gondo Y, Steinberg

MH, Hirose N, Atzmon G, Ruvkun G, Baldwin CT, Perls TT. PLoS One.;4(12):e8210.

Biological approaches to mechanistically understand the healthy life span extension achieved

by calorie restriction and modulation of hormones. Barzilai N, Bartke A. J Gerontol A Biol Sci

Med Sci. 2009 Feb;64(2):187-91.

Ashkenazi Jewish centenarians do not demonstrate enrichment in mitochondrial haplogroup

J. Shlush LI, Atzmon G, Weisshof R, Behar D, Yudkovsky G, Barzilai N, Skorecki K. PLoS

One. 2008;3(10):e3425.

pairment. Koh MT, Haberman RP, Foti S, McCown TJ, Gallagher M. Neuropsychopharma-

cology. 2009 Dec 23.

Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Haberman RP,

Colantuoni C, Stocker AM, Schmidt AC, Pedersen JT, Gallagher M. Neurobiol Aging. 2009

Cognitive aging: a common decline of episodic recollection and spatial memory in rats. Rob-

itsek RJ, Fortin NJ, Koh MT, Gallagher M, Eichenbaum H. J Neurosci. 2008; 28(36):8945-

8954.

Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy.

Fan Y, Dutta J, Gupta N, Fan G, Gélinas C. Adv Exp Med Biol. 2008;615:223-50.

Molecular Basis of Oncogenesis by NF-κB: From a Bird’s Eye View to a RELevant Role in Can-

cer. Yongjun Fan, Jui Dutta, Nupur Gupta and Céline Gélinas NF-κB/Rel Transcription Fac-

tor Family; Molecular Biology Intelligence Unit; Springer US; 2006; р. 112-130.

Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is

important for lymphocyte transformation by rel proteins.

Gupta N, Delrow J, Drawid A, Sengupta AM, Fan G, Gélinas C. Cancer Res. 2008 Feb

1;68(3):808-14.

Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?

D. Gems, R. Doonan. Cell Cycle. 2009. 8: 1681-1687

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/

IGF-1 receptor. 'D.S. Patel, A. Garza-Garcia, M. Nanji, J.J. McElwee, D. Ackerman, P.C.

Driscoll, D. Gems. Genetics. 2008. 178: 931-946.

Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans. D. Mc-

Culloch, D. Gems. Annals of the New York Academy of Sciences. 2007

Основные публикации

по теме

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor

growth in a mouse skin cancer pain model. Gao YJ, Cheng JK, Zeng Q, Xu ZZ, Decosterd I,

Xu X, Ji RR; 2009

MAP kinase and pain. Ji RR, Gereau RW, Malcangio M, Strichartz GR; 2009

Activation of JNK pathway in persistent pain. Gao YJ, Ji RR; 2008

Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes. Fan

X, Zhang J, Theves M, Strauch C, Nemet I, Liu X, Qian J, Giblin FJ, Monnier VM. J Biol

Chem. 2009 Oct 23.

Methionine sulfoxide reductase A (MsrA) restores alpha-crystallin chaperone activity lost upon

methionine oxidation. Brennan LA, Lee W, Giblin FJ, David LL, Kantorow M. Biochim Bio-

phys Acta. 2009 Sep 3.

press).

Factors impacting human telomere homeostasis and age-related disease. Gilley, D., Herbert,

B-S., H. Tanaka, Huda N., and T. Reed (2008). Mechanisms of Ageing and Development 29,

27-34.

Shared environmental factors associated with telomere length maintenance in elderly male twins

Huda, N., H. Tanaka, B-S. Herbert, T. Reed, and D. Gilley, (2007) . Aging Cell 6, 709-13.

Salgado AJ, Reis RL, Sousa N, Gimble JM. Adipose Tissue Derived Stem Cells Secretome:

Soluble Factors and Their Roles in Regenerative Medicine // Curr Stem Cell Res Ther, 2009

The epigenetics of adult (somatic) stem cells. Eilertsen KJ, Floyd Z, Gimble JM. Crit Rev Eu-

karyot Gene Expr. 18(3):189-206, 2008

Differentiation of adipose stem cells. Bunnell BA, Estes BT, Guilak F, Gimble JM. Methods

Mol Biol. 456:155-71, 2008

Proteasome activation as a novel antiaging strategy. Chondrogianni N, Gonos ES.IUBMB

Life. 2008 Oct;60(10):651-5.

Proteasome dysfunction in mammalian aging: steps and factors involved. Chondrogianni N,

Gonos ES.Exp Gerontol. 2005 Dec;40(12):931-8. Epub 2005 Oct 24.

Oxidative stress in malignant progression: The role of Clusterin, a sensitive cellular biosensor of

free radicals

Trougakos IP, Gonos ES. Adv Cancer Res. 2009;104:171-210.

Основные публикации

по теме

Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Gorbu-

nova, V., and A. Seluanov. 2008Mech. Aging Dev., In press (Invited review)

Use of Rad51 promoter for targeted anticancer therapy. Hine, C., Seluanov, A., and V. Gorbu-

nova. 2008Proc Natl Acad Sci 105(53):20810-5.

Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan.

Seluanov, A., Hine, C., Bozzella, M., Hall, A., Sasahara, T.H.C., Ribeiro, A.A.C.M., Cata-

nia, K.C., Presgraves, D.C., and V. Gorbunova. 2008. Aging Cell 7(6):813-823.

Rodents for comparative aging studies: from mice to beavers Gorbunova, V., Bozella, M., and

A. Seluanov. 2008. Age 30(2-3):111-119.

Schwanninger A, Weinberger B, Almanzar G, Parson W, Buus S, Lindner H, Grubeck-Loeben-

stein B. J Leukoc Biol. 2010 Jan;87(1):165-172.

CD28(-)CD8(+) T cells do not contain unique clonotypes and are therefore dispensable. Wein-

berger B, Welzl K, Herndler-Brandstetter D, Parson W, Grubeck-Loebenstein B. Immunol Lett.

2009 Dec 2;127(1):27-32.

The aging of the immune system. Weiskopf D, Weinberger B, Grubeck-Loebenstein B. Transpl

Int. 2009 Nov;22(11):1041-50. Epub 2009 Jul 16.

A dual-hit animal model for age-related parkinsonism. Boger HA, Granholm AC, McGinty JF,

Middaugh LD. Prog Neurobiol. 2009 Oct 21.

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse

model. Lockrow J, Prakasam A, Huang P, Bimonte-Nelson H, Sambamurti K, Granholm AC.

Exp Neurol. 2009 Apr;216(2):278-89.

Mood, memory and movement: an age-related neurodegenerative complex? Granholm AC,

Boger H, Emborg ME. Curr Aging Sci. 2008 Jul;1(2):133-9.

High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition. Chiu YL, Wit-

kowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC:Proc Natl

Acad Sci USA 2006, 103:15588-15593.

The APOBEC3 cytidine deaminases: An innate defensive network opposing exogenous retro-

viruses and endogenous retroelements. Chiu Y-L, Greene WC (2008) Ann. Rev. Immunol.

26:317–353.

дований в терапии. Громова О.А, Гоголева И.В. Фарматека. 2007. том 146, №12. С.

3–6].

Дисплазия соединительной ткани, клеточная биология и молекулярные механизмы

воздействия магния. И.Ю. Торшин, О.А. Громова

Основные публикации

по теме

Mutation in the silencing gene SIR4 can delay aging in Saccharomyces cerevisiae. Kennedy,

B., Austriaco, N., Zhang, J., and Guarente, L. Cell, 1995. 80, 485-496.

Link between aging and the nucleolus. Guarente, L. Genes and Devel. 1997. 11, 2449-2555.

Genetic pathways that regulate aging in model organisms.Guarente, L. and Kenyon, C. Na-

ture, 2000, 408, 255-262.

SIR2 and aging—the exception that proves the rule. Guarente, L. Trends Gen. 2001, 17, 393-

393.

Making a neuron: Cdk5 in embryonic and adult neurogenesis. Jessberger S, Gage FH, Eisch

AJ, Lagace DC. Trends Neurosci. 2009 Nov;32(11):575-82.

Signaling in adult neurogenesis. Suh H, Deng W, Gage FH. Annu Rev Cell Dev Biol.

2009;25:253-75.

Development of neural circuits in the adult hippocampus. Li Y, Mu Y, Gage FH. Curr Top Dev

Biol. 2009;87:149-74.

Stem-cell-associated structural and functional plasticity in the aging hippocampus. Jessberger

S, Gage FH. Psychol Aging. 2008 Dec;23(4):684-91.

Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development. Guizzetti M, Costa

LG. J Pediatr Hematol Oncol. 2008 Sep;30(9):641-642.

Neurotoxicity of pesticides: a brief review. Costa LG, Giordano G, Guizzetti M, Vitalone A.

Front Biosci. 2008 Jan 1;13:1240-1249.

Manganese inhibits the ability of astrocytes to promote neuronal differentiation. Giordano

G, Pizzurro D, VanDeMark K, Guizzetti M, Costa LG. Toxicol Appl Pharmacol. 2009 Oct

15;240(2):226-235.

Modulation of neuritogenesis by astrocyte muscarinic receptors.

Guizzetti M, Moore NH, Giordano G, Costa LG. J Biol Chem. 2008 Nov 14;283(46):31884-

31897.

Effects of small molecules on chaperone-mediated autophagy.

Finn PF, Mesires NT, Vine M, Dice JF. Autophagy. 2005 Oct-Dec

A molecular chaperone complex at the lysosomal membrane is required for protein transloca-

tion. Agarraberes FA, Dice JF. Cell Sci. 2001 Jul

Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal

sequence for chaperone-mediated transport. Susan PP, Dunn WA Jr. J Cell Physiol. 2001 Apr

Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis. Lenk

SE, Susan PP, Hickson I, Jasionowski T, Dunn WA Jr. J Cell Physiol. 1999 Jan

Autophagy in the heart and liver during normal aging and calorie restriction. Wohlgemuth

SE, Julian D, Akin DE, Fried J, Toscano K, Leeuwenburgh C, Dunn WA Jr. Rejuvenation

Res. 2007 Sep

Основные публикации

по теме

Immune remodeling: lessons from repertoire alterations during chronological aging and in

immune-mediated disease. Vallejo AN. Trends Mol Med. 2007 Mar;13(3):94-102.

Age-dependent alterations of the T cell repertoire and functional diversity of T cells of the aged.

Vallejo AN. Immunol Res. 2006;36(1-3):221-8.