- •Contents
- •Contributors
- •Brain Tumor Imaging
- •1 Introduction
- •1.1 Overview
- •2 Clinical Management
- •3 Glial Tumors
- •3.1 Focal Glial and Glioneuronal Tumors Versus Diffuse Gliomas
- •3.3 Astrocytomas Versus Oligodendroglial Tumors
- •3.4.1 Diffuse Astrocytoma (WHO Grade II)
- •3.5 Anaplastic Glioma (WHO Grade III)
- •3.5.1 Anaplastic Astrocytoma (WHO Grade III)
- •3.5.3 Gliomatosis Cerebri
- •3.6 Glioblastoma (WHO Grade IV)
- •4 Primary CNS Lymphomas
- •5 Metastatic Tumors of the CNS
- •References
- •MR Imaging of Brain Tumors
- •1 Introduction
- •2 Brain Tumors in Adults
- •2.1 Questions to the Radiologist
- •2.2 Tumor Localization
- •2.3 Tumor Malignancy
- •2.4 Tumor Monitoring
- •2.5 Imaging Protocol
- •Computer Tomography
- •2.6 Case Illustrations
- •3 Pediatric Brain Tumors
- •3.1 Standard MRI
- •3.2 Differential Diagnosis of Common Pediatric Brain Tumors
- •3.3 Early Postoperative Imaging
- •3.4 Meningeal Dissemination
- •References
- •MR Spectroscopic Imaging
- •1 Methods
- •1.1 Introduction to MRS
- •1.2 Summary of Spectroscopic Imaging Techniques Applied in Tumor Diagnostics
- •1.3 Partial Volume Effects Due to Low Resolution
- •1.4 Evaluation of Metabolite Concentrations
- •1.5 Artifacts in Metabolite Maps
- •2 Tumor Metabolism
- •3 Tumor Grading and Heterogeneity
- •3.1 Some Aspects of Differential Diagnosis
- •4 Prognostic Markers
- •5 Treatment Monitoring
- •References
- •MR Perfusion Imaging
- •1 Key Points
- •2 Methods
- •2.1 Exogenous Tracer Methods
- •2.1.1 Dynamic Susceptibility Contrast MRI
- •2.1.2 Dynamic Contrast-Enhanced MRI
- •3 Clinical Application
- •3.1 General Aspects
- •3.3 Differential Diagnosis of Tumors
- •3.4 Tumor Grading and Prognosis
- •3.5 Guidance for Biopsy and Radiation Therapy Planning
- •3.6 Treatment Monitoring
- •References
- •Diffusion-Weighted Methods
- •1 Methods
- •2 Microstructural Changes
- •4 Prognostic Marker
- •5 Treatment Monitoring
- •Conclusion
- •References
- •1 MR Relaxometry Techniques
- •2 Transverse Relaxation Time T2
- •4 Longitudinal Relaxation Time T1
- •6 Cest Method
- •7 CEST Imaging in Brain Tumors
- •References
- •PET Imaging of Brain Tumors
- •1 Introduction
- •2 Methods
- •2.1 18F-2-Fluoro-2-Deoxy-d-Glucose
- •2.2 Radiolabeled Amino Acids
- •2.3 Radiolabeled Nucleoside Analogs
- •2.4 Imaging of Hypoxia
- •2.5 Imaging Angiogenesis
- •2.6 Somatostatin Receptors
- •2.7 Radiolabeled Choline
- •3 Delineation of Tumor Extent, Biopsy Guidance, and Treatment Planning
- •4 Tumor Grading and Prognosis
- •5 Treatment Monitoring
- •7 PET in Patients with Brain Metastasis
- •8 Imaging of Brain Tumors in Children
- •9 Perspectives
- •References
- •1 Treatment of Gliomas and Radiation Therapy Techniques
- •2 Modern Methods and Strategies
- •2.2 3D Conformal Radiation Therapy
- •2.4 Stereotactic Radiosurgery (SRS) and Radiotherapy
- •2.5 Interstitial Brachytherapy
- •2.6 Dose Prescription
- •2.7 Particle Radiation Therapy
- •3 Role of Imaging and Treatment Planning
- •3.1 Computed Tomography (CT)
- •3.2 Magnetic Resonance Imaging (MRI)
- •3.3 Positron Emission Tomography (PET)
- •4 Prognosis
- •Conclusion
- •References
- •1 Why Is Advanced Imaging Indispensable for Modern Glioma Surgery?
- •2 Preoperative Imaging Strategies
- •2.4 Preoperative Imaging of Function and Functional Anatomy
- •2.4.1 Imaging of Functional Cortex
- •2.4.2 Imaging of Subcortical Tracts
- •3 Intraoperative Allocation of Relevant Anatomy
- •Conclusions
- •References
- •Future Methods in Tumor Imaging
- •1 Special Editing Methods in 1H MRS
- •1.1 Measuring Glycine
- •2 Other Nuclei
- •2.1.1 Spatial Resolution
- •2.1.2 Measuring pH
- •2.1.3 Measuring Lipid Metabolism
- •2.1.4 Energy Metabolism
- •References
Brain Tumor Imaging
Oliver Bähr, Joachim P. Steinbach, and Michael Weller
Contents
1 |
Introduction |
1 |
|
|
1.1 |
Overview |
1 |
2 |
Clinical Management |
2 |
|
3 |
Glial Tumors |
2 |
|
|
3.1 |
Focal Glial and Glioneuronal Tumors |
|
|
|
Versus Diffuse Gliomas |
2 |
|
3.2 |
Low-Grade Versus High-Grade Gliomas |
3 |
|
3.3 |
Astrocytomas Versus Oligodendroglial Tumors |
3 |
|
3.4 |
Low-Grade Glioma (WHO Grade II) |
3 |
|
3.5 |
Anaplastic Glioma (WHO Grade III) |
4 |
|
3.6 |
Glioblastoma (WHO Grade IV) |
5 |
4 |
Primary CNS Lymphomas |
6 |
|
5 |
Metastatic Tumors of the CNS |
6 |
|
References |
7 |
Abstract
The variety of brain tumors with different histology, localization, age distribution, and prognosis might be confusing. The WHO Classification of Tumours of the Central Nervous system (2007) includes more than 100 different entities (Louis et al. 2007). The comparison of primary brain and CNS tumors by site and by histology facilitates a first insight (Ostrom et al. 2014). Moreover, this reflects the incidence rates of specific brain tumors. Besides metastatic tumors of the CNS, meningeal tumors and glioma account for more than 60 % of all primary brain tumors. Regarding malignant tumors, gliomas even represent 80 % of all primary brain tumors. From 45 years of age and older, meningioma is the most frequent and glioblastoma the second most frequent brain tumor. In children and adolescents, pilocytic astrocytoma and embryonal tumors are more relevant (Ostrom et al. 2014).
O. Bähr (*) • J.P. Steinbach
Dr. Senckenberg Institute of Neurooncology, University Cancer Center, Goethe University Hospital, Frankfurt, Germany
e-mail: oliver.baehr@med.uni-frankfurt.de; joachim.steinbach@med.uni-frankfurt.de
M. Weller
Department of Neurology,
University Hospital Zurich,
Zurich, Switzerland
1Introduction
1.1Overview
The variety of brain tumors with different histology, localization, age distribution, and prognosis might be confusing. The WHO Classification of Tumours of the Central Nervous system (2007) includes more than 100 different entities (Louis et al. 2007). The comparison of primary brain and CNS tumors by site and by histology facilitates a first insight (Ostrom et al. 2014). Moreover, this reflects the incidence rates of specific brain tumors. Besides metastatic tumors of the CNS, meningeal tumors and glioma account for more than 60 % of all primary brain tumors. Regarding malignant tumors, gliomas even represent 80 % of all primary brain tumors. From 45 years of age and older, meningioma is the most frequent and glioblastoma the second most frequent brain tumor. In children and adolescents, pilocytic astrocytoma and embryonal tumors are more relevant (Ostrom et al. 2014).
E. Hattingen, U. Pilatus (eds.), Brain Tumor Imaging, |
1 |
Med Radiol Radiat Oncol (2016)
DOI 10.1007/174_2016_1072, © Springer Berlin Heidelberg